Best-rated hotels in Sikeston for your unforgettable stay

Detailed descriptions, travelers’ reviews, and handpicked hotel collections will help you book your perfect accommodation.

Check-in date:
Check-out date:
0 Adults

Adults

0 Children

Children

Apply

Why book with us?

Choose from exclusive hotel collection

We offer thousands of Sikeston hotels and accommodations from world's renowned hotel chains to unique gems of the region you won’t find anywhere else.

Enjoy seamless booking experience

Once you choose your best place to stay, take a minute to complete a quick reservation form and get an instant confirmation letter to your email address.

Benefit from flexible travel options

We provide the most flexible cancellation options, so you get your deposit back in case of a change of plans or other unforeseen circumstances.

Find a hotel

Hotels by class
2 stars 4
Thematic Hotels
Luxury accommodations 10
Hotels with indoor pool 8
Business hotels 7
Exceptional design hotels 4
Jacuzzi 2
Romantic hotels 2
Golf hotels 1
Historical hotels 1
Sustainability certification 1
Extended Stay 1

Hotels by location

Nearby
Granny's Antiques and Semo AG 9
Sikeston Sports Complex 13
Sikeston Beauty College 8
Sikeston Missouri Arts 9
Parks and Recreation 9
Intl College of Bible Theology Sikeston 5
Landmarks
Stadiums
Museums
Parks
Popular attractions

Welcome to Sikeston

Plan your next adventure to Sikeston, a charming city in Missouri where history and natural beauty collide. Explore the historic downtown, indulge in authentic southern cuisine, and witness the famous Sikeston Jaycee Bootheel Rodeo. Immerse yourself in the warmth of its locals, the vibrancy of its festivals, and the breathtaking beauty of its parks. Discover the hidden gems and make unforgettable memories in Sikeston. Come and experience it for yourself!

What our users say about Sikeston hotels

9.8

Exceptional

us Eugene 27 November 2022
We liked the hotel, ideal for our purposes. The restaurant was just a pleasant stroll away from the property.
Read more +
Show Less -
9.8

Exceptional

us Gloria 20 October 2022
The hotel was convenient and fairly clean inside, I loved it. The staff were all amicable, knowledgeable.
Read more +
Show Less -
9.8

Exceptional

us James 24 February 2023
All the staff is helpful and is engaged to make your stay nice. The location is best possible and ideal, not too far from Night.
Read more +
Show Less -
9.8

Exceptional

us Thomas 31 December 2022
The staff here are friendly and willing to help at any time. We had a double room with a lovely garden view 🌿 and everything in the room was in good working order.
Read more +
Show Less -
9.8

Exceptional

us Kathryn 02 April 2023
This place is beautiful, clean, and deserves a rating higher than 4 stars, providing a comfortable and convenient location.
Read more +
Show Less -
9.8

Exceptional

us William 30 September 2022
The hotel is unique and clean, with spectacular views of downtown. the room was immaculate and impressive, with a private bathroom, shower, hairdryer, and terry bathrobes. the location is favorable and unbeatable in the St Louis arts district, with easy access to restaurants and the Sheldon theater.
Read more +
Show Less -
9.8

Exceptional

us David 18 July 2021
Everything was lovely and spotless, I liked staff and rooms. Nice lobby.
Read more +
Show Less -
9.4

Excellent

us Leon 28 February 2023
The staff here was friendly and really helped us out. We're already planning our next trip back. It was a great spot to see the sights and we had a blast! 😊
Read more +
Show Less -
9.8

Exceptional

us Edmund 29 March 2022
The hotel was straightforward and the location was cozy near to Busch stadium as well as the river. Light, gorgeous room with a let out couch.
Read more +
Show Less -
9.8

Exceptional

us Robert 05 July 2022
I loved that the hotel was stunningly beautiful and fairly clean. The room was well stocked, terrific. I had a marvellous view here. I had a very very good stay and would have extended the stay, thank you.
Read more +
Show Less -

Save time on your trip arrangements by booking one of our hand-picked hotels

Best 4-star hotels
Exclusive 3-star hotels
Quality 2-star hotels
Experience the best value for your money by checking out our selection of 4-star Sikeston hotels.
Travel Inn And Suites- Sikeston Miner I-55 Exit-67

100 Matthews Lane, Sikeston, United States

Good
455 reviews

60 US$

min. price/night

Enjoy truly authentic experiences without compromising comfort and convenience.
Drury Inn & Suites Sikeston

2608 E Malone, Sikeston, United States

Excellent
752 reviews

130 US$

min. price/night

Best Western Plus Sikeston I-55

120 S Interstate Drive, Sikeston, United States

Good
304 reviews

98 US$

min. price/night

Comfort Inn & Suites Sikeston I-55

109 Matthews Lane, Sikeston, United States

Good
201 reviews

108 US$

min. price/night

Super 8 By Wyndham Sikeston/Miner Area Hotel

2609 E Malone, Sikeston, United States

Good
169 reviews

70 US$

min. price/night

Discover the hidden gems of Sikeston by booking one of its budget-friendly hotels.
Pear Tree Inn Sikeston

2602 East Malone Avenue, Sikeston, United States

Excellent
833 reviews

90 US$

min. price/night

Days Inn And Suites By Wyndham Sikeston

220 South Interstate Dr, Sikeston, United States

Good
227 reviews

74 US$

min. price/night

Country Yard Inn Sikeston - Miner Exit 67 On I-55

110 South Interstate Drive, Sikeston, United States

Average
103 reviews

56 US$

min. price/night

Motel 6-Sikeston, Mo

110 South Interstate Drive, Sikeston, United States

60 US$

min. price/night

Thank you for your feedback

Close