Best-rated hotels in Saint Charles for your unforgettable stay

Detailed descriptions, travelers’ reviews, and handpicked hotel collections will help you book your perfect accommodation.

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Choose from exclusive hotel collection

We offer thousands of Saint Charles hotels and accommodations from world's renowned hotel chains to unique gems of the region you won’t find anywhere else.

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Once you choose your best place to stay, take a minute to complete a quick reservation form and get an instant confirmation letter to your email address.

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We provide the most flexible cancellation options, so you get your deposit back in case of a change of plans or other unforeseen circumstances.

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Hotels by class
5 stars 2
4 stars 1
3 stars 14
2 stars 3
Unrated 43
Accommodation type
Apartments 25
Hotels 21
Holiday homes 14
Resort 1
Guest house 1
Inn 1
Thematic Hotels
Vacation Rentals 38
Extended Stay 38
Pet-friendly hotels 36
Luxury accommodations 31
Family Friendly hotels 18
Cheap and budget hotels 17
Hotels with indoor pool 12
Business hotels 11
Golf hotels 4
Private Villas 4
Jacuzzi 4
Sustainability certification 4
Exceptional design hotels 3
Historical hotels 3
Central hotels 3
Boutique hotels 3
Luxury hotels 3
Spa hotels 2
Resorts 1
Casino hotels 1
Romantic hotels 1
Travel Proud 1
All Saint Charles hotels

Hotels by location

Nearby
City Center Saint Charles 33
Great Skate Roller Rink Saint Charles 6
Harvester Square 36
Lindenwood University Saint Charles 39
Zumbehl Commons Shopping Center 26
Ameristar Casino St. Charles 35
American Legion Saint Charles 38
Blanchette Park 31
Charles County Parks Dept 36
Conservatory Saint Charles 36
Grand Prix Karting Saint Charles 6
St Charles Convention Center 37
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Missouri >
Saint Charles

Welcome to Saint Charles

Nestled in the heart of Missouri, Saint Charles offers a charming glimpse into America's history, with cobblestone streets, vintage shops, and taverns that hark back to the days of the wild west. Immerse yourself in local culture by exploring the Lewis and Clark Boathouse and Nature Center, or by taking a stroll along the Missouri River. With an abundance of delectable dining options and stylish boutique hotels, Saint Charles is the perfect destination for a weekend getaway or a longer, more relaxing stay. Come explore this vibrant city for yourself and experience all that Saint Charles has to offer.

What our users say about Saint Charles hotels

Hyatt Regency Saint Louis At The Arch
9.8

Exceptional

us Eugene 27 November 2022
We liked the hotel, ideal for our purposes. The restaurant was just a pleasant stroll away from the property.
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Palace View Resort By Spinnaker
9.8

Exceptional

us Gloria 20 October 2022
The hotel was convenient and fairly clean inside, I loved it. The staff were all amicable, knowledgeable.
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Hilton St. Louis At The Ballpark
9.8

Exceptional

us James 24 February 2023
All the staff is helpful and is engaged to make your stay nice. The location is best possible and ideal, not too far from Night.
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St. Louis Union Station Hotel, Curio Collection By Hilton
9.8

Exceptional

us Thomas 31 December 2022
The staff here are friendly and willing to help at any time. We had a double room with a lovely garden view 🌿 and everything in the room was in good working order.
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Clayton Plaza Hotel & Extended Stay
9.8

Exceptional

us Kathryn 02 April 2023
This place is beautiful, clean, and deserves a rating higher than 4 stars, providing a comfortable and convenient location.
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Angad Arts Hotel St. Louis, Tapestry Collection By Hilton
9.8

Exceptional

us William 30 September 2022
The hotel is unique and clean, with spectacular views of downtown. the room was immaculate and impressive, with a private bathroom, shower, hairdryer, and terry bathrobes. the location is favorable and unbeatable in the St Louis arts district, with easy access to restaurants and the Sheldon theater.
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Branson King Resort & Suites
9.8

Exceptional

us David 18 July 2021
Everything was lovely and spotless, I liked staff and rooms. Nice lobby.
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The Last Hotel
9.4

Excellent

us Leon 28 February 2023
The staff here was friendly and really helped us out. We're already planning our next trip back. It was a great spot to see the sights and we had a blast! 😊
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Hotelumiere At The Arch Hotel & Casino - A Caesars Rewards Destination
9.8

Exceptional

us Edmund 29 March 2022
The hotel was straightforward and the location was cozy near to Busch stadium as well as the river. Light, gorgeous room with a let out couch.
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Grand Crowne Resort
9.8

Exceptional

us Robert 05 July 2022
I loved that the hotel was stunningly beautiful and fairly clean. The room was well stocked, terrific. I had a marvellous view here. I had a very very good stay and would have extended the stay, thank you.
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Save time on your trip arrangements by booking one of our hand-picked hotels

Top 5-star hotels
Best 4-star hotels
Exclusive 3-star hotels
Quality 2-star hotels
Indulge yourself with luxury and comfort as you explore the exciting attractions of Saint Charles.
Country Inn & Suites By Radisson, St Charles Historic District

1190 South Main Street, Saint Charles, United States

Excellent
1076 reviews

118 US$

min. price/night

Ameristar Casino Resort And Spa

1 Ameristar Boulevard, Saint Charles, United States

Excellent
81 reviews

101 US$

min. price/night

Experience the best value for your money by checking out our selection of 4-star Saint Charles hotels.
Comfort Suites St Charles-St Louis

1400 S. Fifth Street, Saint Charles, United States

Good
579 reviews

146 US$

min. price/night

Enjoy truly authentic experiences without compromising comfort and convenience.
Drury Plaza Hotel St. Louis St. Charles

380 Mulholland Dr, Saint Charles, United States

Excellent
486 reviews

140 US$

min. price/night

Best Western Plus The Charles Hotel

1425 S 5Th Street, Saint Charles, United States

Good
402 reviews

86 US$

min. price/night

Embassy Suites By Hilton Saint Louis Saint Charles

Two Convention Center Plaza, Saint Charles, United States

Excellent
325 reviews

129 US$

min. price/night

Tru By Hilton St. Charles St. Louis Hotel

333 Camelback Road, Saint Charles, United States

Excellent
169 reviews

194 US$

min. price/night

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Discover the hidden gems of Saint Charles by booking one of its budget-friendly hotels.
Relax Inn Saint Charles

3800 Harry S. Truman Boulevard, Saint Charles, United States

Good
775 reviews

70 US$

min. price/night

Holiday Inn Express Hotel & Suites St. Charles By Ihg

3098 Elm Point Industrial Drive, Saint Charles, United States

Excellent
101 reviews

134 US$

min. price/night

Candlewood Suites St. Louis - St. Charles By Ihg

1800 Zumbehl Road, Saint Charles, United States

Travelers’ choice

Check out the most booked accommodations to find reliable places that our users have tried and tested.
Super 8 By Wyndham St Charles Hotel

3040 West Clay, Saint Charles, United States

Good
389 reviews

57 US$

min. price/night

Boone'S Lick Trail Inn

1000 South Main Street, Saint Charles, United States

Excellent
16 reviews

212 US$

min. price/night

Main Street Apartment For Up To 8 Guests!

334 N. Main Street Apartment A, Saint Charles, United States

Excellent
15 reviews

269 US$

min. price/night

The Historic Bricks On Main Apartment

213 N. Main Street

Good
13 reviews

160 US$

min. price/night

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